Many of these drugs are available by prescription, in which case, a valid medical prescription would help to resolve the issue, although it must be remembered that abuse of a prescription drug is still abuse. These drugs have been described and reviewed in several publications.
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Precursor in this case refers to compounds that are metabolically converted to methamphetamine and/or amphetamine by the body. Likewise, presence of l-methamphetamine in a sample, which is allegedly the result of administration of desoxyn® (contains only d-methamphetamine), would clearly demonstrate the legitimate medication was not the source of the drug found.Īnother potential source for amphetamine and/or methamphetamine are precursor drugs. For example, the presence of d-methamphetamine in a sample, which is alleged to be the result of the use of a Vicks® inhaler, would disprove the assertion without question since the inhaler contains the l-enantiomer. While this does not allow for the demonstration that a drug was from a legitimate medical source, inconsistent findings can easily exclude a legitimate source. Prescription drugs can be characterized by their enantiomer composition. Enantiomer analysis can also be a very useful tool in the evaluation of the source of the drug. Obviously, those drugs that contain amphetamine would not give rise to methamphetamine, which can eliminate several potential sources for the drug. , describe the profiling of contaminants found in the illicit preparation of methamphetamine as a means of identification of the source of the drug as not being legitimate.
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Pharmaceutical amphetamine and methamphetamine are high purity drugs that can often be separated from illicitly produced drugs that typically are not purified to the high degree seen in the legitimate pharmaceutical industry. There is much, however, that can be determined by evaluation of the drug, its metabolites, potential precursors and impurities. Interpretation of the source of the amphetamine and/or methamphetamine is a difficult task. Cody, in Handbook of Analytical Separations, 2008 3.7.2 Source Differentiation